性别

女

出生年月

电话

E-mail

职位/职称

副研究员

人才类别

教育经历：

起止时间

学位

毕业院校

专业学科

2009-9 — 2013-7

工学学士

山东农业大学

制药工程（农药）

2013-8 — 2018-6

理学博士学位

中国农业大学

农药学

工作经历：

起止时间

工作单位

职位/职称

2018-7 — 2021-12

浙江大学

研究方向和研究领域简介：

1.重要靶点的药物分子设计

2.基于大尺度分子模拟的蛋白-配体作用机制研究

主持课题：

1. 抗去势抵抗性前列腺癌的GR调节剂的发现与活性研究-2026/12/31

2. 靶向EcR新型广谱蜕皮激动剂的设计、合成与活性研究-2022/12/31

代表性研究成果：

1. Li Dan. Discovery and Optimization of N-Acyl-6-sulfonamide-tetrahydroquinoline Derivatives as Novel Non-Steroidal Selective Glucocorticoid Receptor Modulators. J. Med. Chem. , 2022.

2. Zhang, Ping. Enantiomer-Specific Study of Fenpropathrin in Soil-Earthworm Microcosms: Enantioselective Bioactivity, Bioaccumulation, and Toxicity. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY Journal, 2022.

3. Xueping Hu , Jingping Pang , Jintu Zhang , Chao Shen , Xin Chai , Ercheng Wang , Haiyi Chen , Xuwen Wang , Mojie Duan , Weitao Fu , Lei Xu , Yu Kang , Dan Li , Hongguang Xia and Tingjun Hou. Discovery of novel GR ligands towards druggable GR antagonist conformations identified by MD Simulations and Markov state model analysis. Adv Sci, 9, e2102435, 2022.

4. Xueping Hu , Jinping Pang , Changwei Chen , Dejun Jiang , Chao shen , Xin Chai , Liu Yang , Xujun Zhang , Lei Xu , Sunliang Cui , Tingjun Hou and Dan Li. Discovery of novel non-steroidal selective glucocorticoid receptor modulators by structure-and IGN-based virtual screening, structural optimization, and biological evaluation. Eur J Med Chem, 114382, 2022.

5. Xueping Hu , Liu Yang , Xin Chai , Yixuan Lei , Md Shah Alam , Lu Liu , Chao Shen , Dejun Jiang , Zhe Wang , Zhiyong Liu , Lei Xu , Kanglin Wan , Tianyu Zhang , Yuelan Yin , Dongsheng Cao , Dan Li and Tingjun Hou. Discovery of novel DprE1 inhibitors via computational bioactivity fingerprints and structure-based virtual screening. Acta Pharmacol Sin, 43, 1605–1615, 2022.

6. Changwei Chen , Xin Chai , Xueping Hu , Shengying Lou , Dan Li , Tingjun Hou and Sunliang Cui. Discovery of 2-(1-(3-Chloro-4-cyanophenyl)-1H-pyrazol-3-yl)acetamides as Potent, Selective, and Orally Available Antagonists Targeting the Androgen Receptor. J. Med. Chem., 2022.

7. Dan Li , Xiaodong Bao , Jinping Pang , Xueping Hu , Longling Wang , Jiajia Wang , Zhaoxu Yang , Lei Xu , Siyu Wang , Qinjie Weng , Sunliang Cui and Tingjun Hou. Discovery and Optimization of N-acyl-6-sulfonamide-tetrahydroquinoline Derivatives as Novel Non-steroidal Selective Glucocorticoid Receptor Modulators. J Med Chem, 65, 15710–15724, 2022.